Intrinsic Activity of Odorant Receptors Guides Sensory Map Formation
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چکیده
منابع مشابه
Intrinsic Activity of Odorant Receptors Guides Sensory Map Formation
Olfactory sensory neurons innervate the olfactory bulb in stereotyped patterns according to the odorant receptors they express. A study by Nakashima et al. in this issue demonstrates that the odorant receptor's level of intrinsic activity-in the absence of activating odorant-influences the guidance of olfactory axons to their targets.
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Sensory systems need to tease out stimulation-evoked activity against a noisy background. In the olfactory system, the odor response profile of an olfactory sensory neuron (OSN) is dependent on the type of odorant receptor it expresses. OSNs also exhibit spontaneous activity, which plays a role in establishing proper synaptic connections and may also increase the sensitivity of the cells. Howev...
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Olfactory sensory neurons expressing a given odorant receptor (OR) project with precision to specific glomeruli in the olfactory bulb, generating a topographic map. In this study, we demonstrate that neurons expressing different ORs express different levels of ephrin-A protein on their axons. Moreover, alterations in the level of ephrin-A alter the glomerular map. Deletion of the ephrin-A5 and ...
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24 25 Sensory systems need to tease out stimulation-evoked activity against a noisy background. In the 26 olfactory system, the odor response profile of an olfactory sensory neuron (OSN) is dependent on the 27 type of odorant receptor it expresses. OSNs also exhibit spontaneous activity, which plays a role in 28 establishing proper synaptic connections and may also increase the sensitivity of t...
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ژورنال
عنوان ژورنال: Cell
سال: 2013
ISSN: 0092-8674
DOI: 10.1016/j.cell.2013.08.037